Fig. 7

MV-Edm protection by GOS in vivo. The nude mice bearing HeLa human cervical carcinoma tumors were randomized into five groups (n = 5 for each group). On day 1 and 14 after inoculation of HeLa cells, mice received peritoneal injection of 500 μl human immune serum containing measles antibodies for 18 h followed by intravenous injection of either naked MV-Edm (purple line) or GOS/MV-Edm (black line). Or mice received the same volume of saline for 18 h followed by intravenous injection of either naked MV-Edm (red line) or GOS/MV-Edm (blue line). The mice treated with saline alone (orange line) or PEI-GOS-PEG-FA alone (green line) were used as controls. Survival of the mice was determined and plotted for survival analysis. Mice were euthanized when the tumor volume reached to 2 cm3 or when they experienced intolerable suffering. All mice surviving at day 100 were euthanized at the end of the study. Statistical testing was performed by log-rank test. # p indicates not significant, *p < 0.05, **p < 0.01