SCP2 and hypercholesterolemia regulated PA cell growth in vivo. a Schematic of dietary challenge and medication administration in mice injected with either Vector or SCP2-OE GH3 cells. HCD stands for high cholesterol diet. b Excised tumors in different groups are shown. c Growth curve showing the changes in the tumor volume in mice after different treatments. d Weight of the excised tumors in each group. e Plasma cholesterol level in mice in each group after sacrifice. f Protein expression level of GLI1 in excised tumors were examined by Western blotting. An unpaired t-test was used to assess statistical significance. **P < 0.01; ***P < 0.001; #, not significant.