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Table 1 Association between CyclinD1/DICER expression and clinicopathologic characteristics

From: CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma

Characteristics Numbers of Patients CyclinD1 P value DICER P value
   Low expression High expression   Low expression High expression  
Age (years)     0.066    0.129
  ≤ 55 21 15 6   17 4  
  > 55 12 8 4   6 6  
Gender     0.295    0.142
 Male 19 10 9   12 7  
 Female 14 8 6   10 4  
Pathology grade     < 0.001*    < 0.001
 Low (I-II) 8 2 6   7 1  
 High (III-IV) 25 9 16   22 3  
TNM stage     0.002*    < 0.001
 I 4 2 2   4 0  
 II 8 2 6   6 2  
 III 11 4 7   10 1  
 IV 10 3 7   8 2  
Lymph node metastasis     0.225    0.265
 Negative 13 7 6   7 6  
 Positive 20 11 9   13 7  
Distant metastasis     0.560    < 0.05
 M0 16 8 8   9 7  
 M1 17 10 7   13 4  
  1. Low expression: IHC staining index≤6; High expression: IHC staining index> 6