CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma

Table 1 Association between CyclinD1/DICER expression and clinicopathologic characteristics

Characteristics	Numbers of Patients	CyclinD1		P value	DICER		P value
		Low expression	High expression		Low expression	High expression
Age (years)				0.066			0.129
≤ 55	21	15	6		17	4
> 55	12	8	4		6	6
Gender				0.295			0.142
Male	19	10	9		12	7
Female	14	8	6		10	4
Pathology grade				< 0.001*			< 0.001
Low (I-II)	8	2	6		7	1
High (III-IV)	25	9	16		22	3
TNM stage				0.002*			< 0.001
I	4	2	2		4	0
II	8	2	6		6	2
III	11	4	7		10	1
IV	10	3	7		8	2
Lymph node metastasis				0.225			0.265
Negative	13	7	6		7	6
Positive	20	11	9		13	7
Distant metastasis				0.560			< 0.05
M0	16	8	8		9	7
M1	17	10	7		13	4

ISSN: 1756-9966