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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma

Fig. 1

MEIS2C/D are overexpressed in hepatocellular carcinoma tissues and associated with poor prognosis. a Quantitative reverse transcriptase PCR (qRT-PCR) analysis showing the expression of MEIS2 in 118 pairs of HCC patient tissues compared adjacent noncancerous livers (ANL). b A schematic drawing of four major splice subtypes of MEIS2 mRNA. Alternative splicing generated two mainly group of MEIS2 isoforms with different C-terminal exon (exon12 vs. exon 13). c Western blot analysis of MEIS2 in 18 random HCC and paired ANL tissues. d Real-time PCR analysis of MEIS2A/B (exon12) and MEIS2C/D (exon13) expression in HCC and matched ANL. e Prognostic significance assessed by Kaplan–Meier estimates method and log-rank test. Comparison of the time to recurrence rate and overall survival by MESI2C/D expression

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