Fig. 3

Apatinib increases radiation-induced apoptosis in HCC cells. a-d Apoptosis was measured at 48 h after IR by FACS using Annexin V FITC/PI double staining assay in HCC cells pretreated with apatinib. e Western blot analysis showed the effects of combination treatment of apatinib with irradiation on the apoptosis markers in SMMC-7721 and MHCC-97H cells. Data is presented as mean ± SEM, *p < 0.05, ** p < 0.01