Fig. 5From: Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinomaInhibition of PI3K/AKT pathway contributes to the radiosensitization effect upon HCC cells. Under irradiation exposure, the effect of LY294002 (a) and MK2206 (b) on SMMC-7721 and MHCC97H cell apoptosis was assessed quantitatively by Annexin V-PI staining assays, respectively. c-d Protein expression of important genes in PI3K/AKT signaling and γ-H2AX were detected by Western blot at 24 h after IRBack to article page