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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway

Fig. 2

LINC00673 promotes breast cancer cell proliferation in vitro. a The LINC00673 expression level in MDA-MB-231, MDA-MB-453, and Hs-578 T breast cancer cells transfected with si-LINC00673 or Lv-LINC00673. b CCK-8 assays were performed to determine the cell viability in MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673. c The colony-forming assays were conducted to examine the proliferation of MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673. d-e CCK-8 and colony-forming assays were used to examine the cell proliferation ability in Lv-LINC00673 transfected Hs-578 T cells. f Cell cycle analysis of MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673 based on flow cytometry. g Flow cytometry analysis of MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673. h Expression of bax, bcl-2 and cyclin D1 in MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673, as determined by western blotting. The data are presented as the mean ± the SD of three independent experiments. *P < 0.05, ** P < 0.01, and *** P < 0.001

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