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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer

Fig. 6

YAP plays a tumor suppressive functions in breast cancer. a YAP1 mRNA expression in breast cancer tissues and normal adjacent tissues from TCGA RNA-seq data. b The protein levels of YAP in twenty two breast cancer tissues and normal tissues were measured by western blot. c Comparison of YAP1 expression in 22 paired breast cancer tissues and normal adjacent tissues by qRT-PCR. d and e Kaplan-Meier plots of overall survival of ER positive breast cancer patients (N = 762) (d) and PR positive breast cancer patients (N = 489) (e) expressing high and low levels of YAP. Data obtained from the Kaplan-Meier plotter database (kmplot.com/analysis). f Schematic illustration for the underlying anti-cancer mechanism of WZ35 in breast cancer. Data are presented as the mean ± SD, ***p < 0.001, ****p < 0.0001

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