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Table 1 Efficacy of immune checkpoint inhibitors in melanoma brain metastases

From: Immunotherapy of brain metastases: breaking a “dogma”

Author Phase Agent No. Patients Intracranial ORR (%)
Margolin (2012) II Ipi   
Cohort A    51 16
Cohort B    21 5
Di Giacomo (2012) II Ipi + Fotemustine 20 50
Parakh (2017) Real-world (retrospective) Nivo or Pembro 66 21
Kluger (2019) II Pembro 23 26
Long (2017) II    
Cohort A   Ipi + Nivo 26 46
Cohort B   Nivo 25 20
Cohort C   Nivo 16 6
Tawbi (2018) II Ipi + Nivo 94 55
  1. Ipi Ipilimumab, Nivo Nivolumab, Pembro Pembrolizumab, ORR Object Response Rate