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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis

Fig. 4

ICAM1 downregulation induces NK cell resistance (a) The viabilities of DU145 and PC3 cells (WT, GFP, and GN) were measured after performing the NK cell resistance assay with or without the ICAM1 neutralizing antibody in vitro (n = 3, *P < 0.005, **P < 0.0001, Student’s t test). (b) Generation of ICAM1-overexpressing GN-DU145 cells. (c) The viabilities of GFP-, GN- and ICAM1/GN-DU145 cells were measured after performing the NK cell resistance assay in vitro (n = 3, *P < 0.01, **P < 0.001, ***P < 0.0001, Tukey-Kramer test). (d) ICAM1/GN- and GN-DU145 cells were transplanted onto SCID mice treated with an anti-asialo GM1 Ab or control IgG. Respective tumor volumes were measured for up to 60 days after the transplantation (n = 4, *P < 0.05, Student’s t test)

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