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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Activity of MCPIP1 RNase in tumor associated processes

Fig. 1

MCPIP1 regulates number of processes directly. MCPIP1 physically interacts with stem-loop structures in the 3′ UTR of transcripts and participates in their degradation. Destabilization of mRNA upon endonucleolytic cleavage by MCPIP1 leads to diminished protein translation and influences on inflammation, adipogenesis, proliferation and apoptosis. MCPIP1 degrades also miRNA by cleaving the terminal loops of precursor miRNAs and influences gene expression

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