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Table 1 Effect of MCPIP1 on gene expression. Regulation of genes expression and proteins level by MCPIP1 was tested both in cells with ZC3H12A overexpression or silencing. Cited results were obtained from studies using cells cultured in control conditions. We did not include data obtained upon induction of differentiation (i.e. adipogenesis), nor stimulation (i.e. cytokines, LPS)

From: Activity of MCPIP1 RNase in tumor associated processes

MCPIP1 OVEREXPRESSION

  gene expression

Experimental model

Reference

  HIF-1α, VEGF1, cdh12, cdh19, VE-cadherina

HUVECs

Niu et al., 2008 [27]

  Ephrin-A1, IL-1β, Notch Homolog 4, Ephrin B2, PDGF α, TIMP-2, Ephrin A3, Midkine, Thrombospondin 1, CSF-3b

  Flt-1, Flk-1, Tie-2, CD31, Beclin-1a

bone marrow mononuclear cells

Niu et al., 2013 [28]

  VEGF, COX2, SIRT-1a

HUVECs

Roy et al., 2013 [29]

  Fas, Dedd2a

MDA-MB-231

Lu et al., 2016 [30]

  MBLN2, SLC3A2, DFFB, APAF1a

BE(2)-C human neuroblastoma cell line

Boratyn et al., 2016 [31]

  CDKN1Aa, c

ccRCC cell line Caki-1

Lichawska-Cieslar et al., 2018 [32]

  gene expression

Experimental model

Reference

  CD14, CD11ba

bone marrow mononuclear cells

Niu et al., 2013 [28]

  TSP-1 and VEGI, p65

HUVECs

Roy et al., 2013 [29]

  Bcl2L1, Bcl2A1, Birc3, RelB, and Bcl3a

MDA-MB-231

Lu et al., 2016 [30]

  CTXN1, CNIH2, MCM10, CD248, RBM12, PAXIP1, SEPT3a

BE(2)-C human neuroblastoma cell line

Boratyn et al., 2016 [31]

  SLC44A1, SLC29A4,

  IL-6, VEGF, GLUT-1a

ccRCC cell line Caki-1

Ligeza et al., 2017 [33]

  c/EBPβ, SDF-1, Snail, Zeb2a

ccRCC cell line Caki-1

Marona et al., 2017 [34]

  HSPA5, AGR2, PLOD2, MMP2, NDRG1, NDRG2, SPHK1, ENPP2,

ccRCC cell line Caki-1

Lichawska-Cieslar et al., 2018 [32]

  NGEF, GPRC5B, TSC22D3, SGK2, FRAT1, RIPK4, DDB1 a, c

MCPIP1 SILENCING

  gene expression

Experimental model

Reference

  BCL2L1, BCL3, BIRC3, RELB, AND BCL2A1

MDA-MB-231

Lu et al., 2016 [30]

  IL-8, VEGF, IL-6, c/EBPβ, SDF-1, CXCR4, Snail, Zeb2a

ccRCC cell line Caki-1

Marona et al., 2017 [34]

  1. aReal-time PCR analysis
  2. bGene array analysis; expression profile of angiogenesis-related genes in GFP/hMCPIP-over GFP-infected HUVECs with fold induction > 5
  3. cRNA-Seq analysis