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Table 1 Effect of MCPIP1 on gene expression. Regulation of genes expression and proteins level by MCPIP1 was tested both in cells with ZC3H12A overexpression or silencing. Cited results were obtained from studies using cells cultured in control conditions. We did not include data obtained upon induction of differentiation (i.e. adipogenesis), nor stimulation (i.e. cytokines, LPS)

From: Activity of MCPIP1 RNase in tumor associated processes

MCPIP1 OVEREXPRESSION
gene expression Experimental model Reference
  HIF-1α, VEGF1, cdh12, cdh19, VE-cadherina HUVECs Niu et al., 2008 [27]
  Ephrin-A1, IL-1β, Notch Homolog 4, Ephrin B2, PDGF α, TIMP-2, Ephrin A3, Midkine, Thrombospondin 1, CSF-3b
  Flt-1, Flk-1, Tie-2, CD31, Beclin-1a bone marrow mononuclear cells Niu et al., 2013 [28]
  VEGF, COX2, SIRT-1a HUVECs Roy et al., 2013 [29]
  Fas, Dedd2a MDA-MB-231 Lu et al., 2016 [30]
  MBLN2, SLC3A2, DFFB, APAF1a BE(2)-C human neuroblastoma cell line Boratyn et al., 2016 [31]
  CDKN1Aa, c ccRCC cell line Caki-1 Lichawska-Cieslar et al., 2018 [32]
gene expression Experimental model Reference
  CD14, CD11ba bone marrow mononuclear cells Niu et al., 2013 [28]
  TSP-1 and VEGI, p65 HUVECs Roy et al., 2013 [29]
  Bcl2L1, Bcl2A1, Birc3, RelB, and Bcl3a MDA-MB-231 Lu et al., 2016 [30]
  CTXN1, CNIH2, MCM10, CD248, RBM12, PAXIP1, SEPT3a BE(2)-C human neuroblastoma cell line Boratyn et al., 2016 [31]
  SLC44A1, SLC29A4,
  IL-6, VEGF, GLUT-1a ccRCC cell line Caki-1 Ligeza et al., 2017 [33]
  c/EBPβ, SDF-1, Snail, Zeb2a ccRCC cell line Caki-1 Marona et al., 2017 [34]
  HSPA5, AGR2, PLOD2, MMP2, NDRG1, NDRG2, SPHK1, ENPP2, ccRCC cell line Caki-1 Lichawska-Cieslar et al., 2018 [32]
  NGEF, GPRC5B, TSC22D3, SGK2, FRAT1, RIPK4, DDB1 a, c
MCPIP1 SILENCING
gene expression Experimental model Reference
  BCL2L1, BCL3, BIRC3, RELB, AND BCL2A1 MDA-MB-231 Lu et al., 2016 [30]
  IL-8, VEGF, IL-6, c/EBPβ, SDF-1, CXCR4, Snail, Zeb2a ccRCC cell line Caki-1 Marona et al., 2017 [34]
  1. aReal-time PCR analysis
  2. bGene array analysis; expression profile of angiogenesis-related genes in GFP/hMCPIP-over GFP-infected HUVECs with fold induction > 5
  3. cRNA-Seq analysis