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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex

Fig. 1

Elevated expression of FOXG1 is associated with metastasis in human HCC. a FOXG1 mRNA levels in hepatocellular carcinoma (HCC) tissue dataset (GSE25097). CIRR: cirrhosis tissues, HEAL: healthy liver tissues, ANT: adjacent non tumor tissues, HCC: hepatocellular carcinoma. b Expression of FOXG1 mRNA and (c) protein in LO2 normal human liver cell line (as comparison control) and the indicated cultured HCC cell lines. GAPDH was used as a loading control. d Western blotting analysis of FOXG1 protein in each of the non-metastatic (N) and metastatic (M) HCC tissue from ten patients. e Expression of FOXG1 protein in 64 non-metastatic (N) and 41 metastatic (M) HCC tissues. f Overall survival of patients with HCC with low vs. high FOXG1 expression. Error bars represent SD from three independent experiments. *P < 0.05

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