Fig. 4

Proliferation of glioblastoma cells. a BrdU incorporation in LN405 72 h after single dose treatment with 0.25 μM SAR, 50 μM TMZ, 0.1 μM 5-aza-dC and/or 8Gy IR. b BrdU incorporation in primary glioblastoma cells 72 h and 7 d after single dose treatment with 0.25 μM SAR and/or 2 Gy IR. a, b Data are weighted means ± medium SEM from three independent experiments (except P0306 7 d post IR, n = 2). c BrdU incorporation 5 d after fractionated treatment with different SAR concentrations and/or 25.9 Gy total IR dose (7 × 3.4 Gy). Data are means ± SEM from one experiment performed at least in triplicates. a-c Statistical significance compared to untreated, non-irradiated control is indicated by asterisks (*, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001), compared to IR alone by hashtags (#, p ≤ 0.05; ##, p ≤ 0.01). In a, all irradiated groups differed significantly compared to untreated, non-irradiated control (p ≤ 0.01) and therefore no further labeling by asterisks is shown