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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways

Fig. 5

BMP3 regulates multiple cellular processes in HCT116 cells. Global mRNA expression profiling was performed for HCT116-BMP3 and control cells (HCT116-Ctr). The experiment was repeated three times for each cell type. KEGG pathway analysis was carried out and affected pathways were categorized as up-regulation (a) and down-regulation (b). c A heat map was generated from hierarchical cluster analysis to visualize genes with differentially expressed mRNAs in the apoptosis and TGF-β signaling pathways. Red and green colors represent those genes with either high or low relative expression, respectively. d Components of apoptosis pathways are displayed. Genes highlighted red are up-regulated. KEGG is Kyoto Encyclopedia of Genes and Genomes

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