Fig. 2

Effects of circWHSC1 on ovarian cancer cell viability, apoptosis, migration and invasion ability. Compared with the group transfected with control vector, overexpression of circWHSC1 in CAOV3 increased cell growth (a), reduced cell apoptosis (c), increased cell migration (e) and invasion rate (g). Down-regulation of circWHSC1 in OVCAR3 exhibited the opposite effects (b, d, f, h). The results are representative of three separate experiments; data are expressed as mean ± SD.* indicates P < 0.05