Fig. 2

Basal lipidomic profiles of breast cancer cells. a The panel illustrates the complement of constitutive lipids determined in breast cancer cells growing under standard conditions. Lipids are classified in the indicated groups on the basis of their general chemical structure. The number of chemical species identified for each class of lipids are indicated on the vertical axis. b The diagram shows a bidimensional principal component analysis (PCA) of the constitutive lipidomic profiles determined in each cell-line exposed to DMSO. c The left PCA analysis illustrates the lipid species whose levels are significantly higher in luminal than basal (green points) and basal than luminal (red points) cell-lines. The right bar graph indicates the lipid classes whose levels are significantly higher in luminal (green bars) and basal (red bars) cell-lines. The data are expressed as in panel (A). o-TG/p-TG = alkyldiacylglycerols/1Z-alkenyldiacylglycerols; TG = triacylglycerols; DG = diacylglycerols; SE = steryl esters; N-glyco-SP = neutral glycosphingolipids; SM = sphingomyelins; CER = ceramides; DHCER = dihydroceramides; SPH/SP = sphingosines/sphinganines; CL = cardiolipins; LBPA/BMP = lysobisphosphatidic acid/ bis(monoacylglycero)phosphate; PS = phosphatidylserines; PI = phosphatidylinositols; PG = phosphatidylglycerol; p-PE = 1-alkyl-2-acylglycerophosphoethanolamines/1-alkenyl-2-acylglycerophosphoethanolamines; PE = phosphatidylethanolamines; o-PC/p-PC = 1-alkyl-2-acylglycerophosphocholines/1-alkenyl-2-acylglycerophosphocholines; PC = phosphatidylcholines; LPE = lysophosphatidylethanolamines; o-LPC/p-LPC = 1-alkyl-glycerophosphocholines/1-alkenyl-glycerophosphocholines; LPC = lysophosphatidylcholines; CAR = acylcarnitines; FA = fatty acids