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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid

Fig. 3

ATRA effects on the levels of N-glyco-sphingolipids, lysophoshatidylcholines and phosphatidylserines. Biological triplicates of the indicated breast cancer cells were treated with vehicle (DMSO) or ATRA (10− 6 M) for 48 h. The box plots show the median ± SD levels of neutral glyco-sphingosines (N-Glyco-SP), lysophoshatidylcholines (LPC) and phosphatidylserines (PS). The number of different molecules identified by mass-spectrometry is indicated in parenthesis. Luminal cell-lines are marked in red and basal cell-lines are marked in blue. The luminal and basal cell-lines are ordered according to decreasing sensitivity to the anti-proliferative effect of ATRA from left to right, as indicated (decreasing ATRA-score). *Significantly different (p < 0.05) from the corresponding vehicle treated control using the Student’s t-test. **Significantly different (p < 0.01) from the corresponding vehicle treated control using the Student’s t-test. The diagrams on the right indicate the correlations between the ATRA/DMSO ratio of the mean values calculated for the indicated lipid class in each cell-line and the corresponding ATRA-score

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