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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid

Fig. 6

Effects of ATRA on the expression of genes involved in the mitochondrial oxidative phosphorylation. Biological triplicates of the indicated breast cancer cells treated with vehicle (DMSO) or ATRA (10− 6 M) for 24 h. Total RNA was extracted and subjected to RNA-seq analysis. a The figure shows the 4 top Hallmark pathways significantly enriched for genes down-regulated by ATRA in sensitive luminal and basal cell-lines ranked according to the enrichment False Discovery Rate (FDR) p-value. b Left: The heat-map shows the expression profiles of the genes belonging to the “Oxidative-Phosphorylation” Hallmark pathway. The results are expressed in log2 values of the ATRA/DMSO ratio as indicated. Right: The heat-map shows the expression profiles of the “Oxidative-Phosphorylation” observed in HCC-1599 cells exposed to ATRA (10− 6 M) for 8 and 24 h. The results are expressed in log2 values of the ATRA/DMSO ratio as indicated. The genes coding for members of the mitochondrial complexes I, II, III, IV and V are marked in different colors. When the genes encode mitochondrial proteins which do not belong to any complex, they are marked in black. The coding genes transcribed from mitochondrial DNA are further indicated by a colored point. The genes down-regulated by ATRA in retinoid sensitive cell-lines are indicated by a black square bracket on the left

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