Table 1 Variables associated with early tumor recurrence after hepatectomy for HCC (N = 144)
Variable | Recurrencea | |||
|---|---|---|---|---|
Univariate analysis P value | Multivariate analysis | |||
P value | Hazard ratio | 95% confidence interval | ||
Gender (male vs. female) | 0.154 | – | – | – |
Age, years (<  55 vs. ≥ 55) | 0.707 | – | – | – |
HBV (yes vs. no) | 0.540 | – | – | – |
HCV (yes vs. no) | 0.647 | – | – | – |
Bilirubin, mg/dL (<  1.2 vs. ≥ 1.2) | 0.863 | – | – | – |
Albumin, g/dL (< 3.5 vs. ≥ 3.5) | 0.252 | – | – | – |
ALT, U/L (<  35 vs. ≥ 35) | 0.207 | – | – | – |
PT, INR (<  1.2 vs. ≥ 1.2) | 0.075 | 0.104 | 2.827 | 0.808–9.885 |
ICG, retention rate (<  15% vs. ≥ 15%) | 0.170 | – | – | – |
TNM stage (T1/2 vs. T3/4) | 0.417 | – | – | – |
Multiple tumors (yes vs. no) | 0.739 | – | – | – |
Child-Pugh class (A vs. B) | 0.251 | – | – | – |
Complete tumor capsule (yes vs. no) | 0.051 | 0.081 | 0.418 | 0.157–1.112 |
Microvascular invasion (yes vs. no) | 0.001b | 0.398 | 1.468 | 0.603–3.578 |
Macrovascular invasion (yes vs. no) | < 0.001b | 0.002b | 11.993 | 2.553–56.339 |
Cut margin free (yes vs. no) | 0.873 | – | – | – |
Differentiation grade (1/2 vs. 3/4) | 0.168 | – | – | – |
Tumor size, cm (<  3 vs. ≥ 3) | 0.039b | 0.554 | 0.788 | 0.359–1.733 |
Satellite nodules (yes vs. no) | 0.008b | 0.969 | 1.019 | 0.393–2.640 |
AFP, ng/mL (<  400 vs. ≥400) | 0.625 | – | – | – |
Serum IL-6, ng/mL (<  150 vs. ≥ 150) | 0.023b | 0.088 | 1.896 | 0.910–3.949 |
Serum TGF-β (<  14,000 vs. ≥ 14,000) | 0.682 | – | – | – |
DNMT1 (< 2X vs. ≥ 2X) | 0.010b | 0.719 | 1.144 | 0.550–2.378 |
DNMT3a (< 2X vs. ≥ 2X) | 0.305 | 0.239 | 1.632 | 0.722–3.689 |
DNMT3b (< 2X vs. ≥ 2X) | 0.037b | 0.199 | 1.779 | 0.739–4.285 |
OCT4 (< 2X vs. ≥ 2X) | 0.026b | 0.085 | 1.990 | 0.909–4.357 |
NANOG (< 2X vs. ≥ 2X) | 0.004b | 0.010b | 3.074 | 1.309–7.220 |
High expression of OCT4 and DNMT3b (< 2X vs. ≥ 2X) | 0.001b | 0.395 | 1.484 | 0.597–3.685 |
High expression of OCT4 and DNMT1 (< 2X vs. ≥ 2X) | 0.013b | 0.226 | 1.754 | 0.705–4.364 |