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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms

Fig. 4

Depletion of CENPM arrested cell cycle and induced cell apoptosis. a FACS analysis showing significant increased or decreased in the proportion of cells in G2/M phase, respectively, when CENPM was knockdown in Huh7 and HepG2 cell or overexpressed in HCCLM3 cells. b Silencing CENPM promoted cell apoptosis in Huh7 and HepG2 cell lines or inhibited cell apoptosis in HCCLM3 cells. c Representative signal pathways of CENPM single-gene GSEA analysis. d Immunofluorescence images showed that CENPM downregulation promoted expression level of nuclear phosphorylated P53. e Western blotting analysis of C-myc, Bcl2, CyclinD1, Bax, P21, cleaved-caspase3 in CENPM-depleted Huh7 and HepG2 cell lines or CENPM-overexpressed HCCLM3 cells. *P < 0.05, **P < 0.01

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