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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms

Fig. 7

miR-1270 negatively regulated CENPM expression in human HCC. a Overexpression of miR-1270 declined CENPM mRNA and protein expression level in Huh7 and HepG2 cells. b CENPM mRNA and protein level was increased after inhibition of miR-1270. c miR-1270 was downregulated in HCC in GSE36915. d IHC of CENPM in HCC samples showed overexpression of miR-1270 reduced CENPM protein levels. e Luciferase reporter assay demonstrated that upregulation of miR-1270 decreased luciferase activity of wild-type CENPM 3′UTR but not that of the mutant. *P < 0.05, **P < 0.01, ***P < 0.001

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