Fig. 6From: Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancerNT1721 displays better antitumor efficacy than gemcitabine and prolongs survival of mice with advanced pancreatic cancer. Male NSG mice were orthotopically implanted with Capan1 luc+ cells. Treatment started with 30 mg/kg NT1721 (three times per week), gemcitabine (100 mg/kg, twice per week) or the vehicle control (n = 7 per group) 12 days (a, b) or 25 days (d) after cell implantation. a Bioluminescent signals. The mice were imaged on the indicated days. The asterisk indicates a significant difference between the control group and treatment groups (NT1721 or gemcitabine) on day 25 (p < 0.05). b Tumor weight after 5 weeks of treatment with NT1721 or gemcitabine. P values were determined using Mann-Whitney test and are indicated in the graphs. c Photos of the representative primary tumors from mice that were treated with NT1721 or gemcitabine and euthanized after 5 weeks of treatment. d Survival curves. Treatment with NT1721 or gemcitabine started on day 25 after tumor implantation (n = 6). The log-rank test was used to determine p values: The difference in survival between the control and gemcitabine treated group was significant (p = 0.029); the difference between the gemcitabine-treated and the NT1721-treated group was also significant (p = 0.0007)Back to article page