Fig. 7

NT1721-mediated changes in gene expression in vivo. a Tumors from individual mice bearing Capan1 tumors were harvested and used for Western blots analysis (n = 4 per group). b Band intensities from (a) were quantified with ImageJ software and normalized to β-actin expression. The graphs represent the ratio of mean value of treated mice to control mice ± SD. p values for the comparison of treated and control mice are indicated above the graphs. c and d Tumors from mice bearing Capan1 tumors (c) or Panc1 tumors (d) were harvested after 5 weeks of treatment with NT1721 or gemcitabine and used for qPCR analysis (n = 4 per group). The data were normalized to ACTB. The graphs show the fold difference ± SD in mRNA expression in NT1721- or gemcitabine-treated mice compared to control mice. P values for the comparison of treated and control mice are indicated above the graphs