Fig. 10

A hypothetical model of CEP-triggered the accumulation of mitophagosomes through blockade of autophagosome-lysosome fusion. CEP triggers downregulation of MYO1C, leading to disrupting the recruitment of MYO1C and F-actin to autophagosomal and lysosomal membranes, resulting in blockade of autophagosome-lysosome fusion, and culminating in the accumulation of mitophagosomes