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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network

Fig. 10

A hypothetical model of CEP-triggered the accumulation of mitophagosomes through blockade of autophagosome-lysosome fusion. CEP triggers downregulation of MYO1C, leading to disrupting the recruitment of MYO1C and F-actin to autophagosomal and lysosomal membranes, resulting in blockade of autophagosome-lysosome fusion, and culminating in the accumulation of mitophagosomes

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