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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873

Fig. 3

STRA6 knockdown promote cell cycle arrest of GC cell in vitro and facilitate tumorigenicity in vivo. a Downregulation of STRA6 promoted G0/G1 cell cycle arrest while ectopic expression of STRA6 presented opposite effect. b The apoptotic rates (Q2 + Q3) of transfected cells were detected by flow cytometry. (Q2, early apoptotic cells; Q3, terminal apoptotic cells). c Cell cycle-related proteins and apoptosis-related proteins were examined by western blot. d and e Images of the subcutaneous xenografts from different groups of nude mice transfected with sh-NC, sh-STRA6, vector and STRA6, respectively. Tumour volumes was calculated after injection every 4 days and tumour growth curves were conducted. (*p < 0.05, **p < 0.01, ***p < 0.001. The data expressed as the mean ± SD)

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