Fig. 4

IL-8 increased HCC cell invasion through CXCR1/2 receptors. a Huh-7 and HepG2 cells were incubated with various concentrations of IL-8 for 24 h, and in vitro invasion was measured with Transwell assay. b After 48 h of transfection with CXCR1 siRNA, CXCR2 siRNA or control siRNA (C siRNA), cells were incubated with IL-8 (100 ng/ml) for 24 h, and in vitro invasion was measured with Transwell assay. Results are expressed as the mean ± SEM. *P < 0.05 compared with the control group. #P < 0.05 compared with the IL-8-treated group