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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

Fig. 7

Proposed model for the activation of the KEAP1/NRF2 pathway by ROS. GSTZ1 deficiency activates the GSH-dependent non-enzymatic bypass to catalyze the conversion of MAA to FAA. The GSH-consuming reaction reduces the antioxidant capacity of cells, thus elevating ROS levels. Increased ROS levels impair the ability of KEAP1 to negatively regulate NRF2, leading to NRF2 nuclear translocation and subsequent transactivation, thus promoting HCC proliferation. ROS, reactive oxygen species; MAA, maleylacetoacetate; FAA, fumarylacetoacetate; GSH, glutathione. Bru, brusatol; NAC, N-acetylcysteine

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