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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies

Fig. 8

Schematic presentation of the anti-inflammatory and anti-angiogenic properties of ALCAR on PCa and BPH cells. Cytokines and chemokines (TNF-α, CCL2, IL-6, CXCL12, CXCL8 and VEGF) regulated in PCa cells and chemokine receptors (CXCR4, CXCR1, CXCR2, CCR2) in HUVEC cells targeted by ALCAR. Blocks indicate inhibited targets by ALCAR treatment observed in our experimental in vitro models

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