Fig. 1

NOTCH2 downregulation is associated with poor prognosis in NPC. a Relative NOTCH2 protein expression in the non-metastatic and metastatic NPC tissues. Scale bar = 50 μm. b Relative NOTCH2 protein expression in the non-metastatic and metastatic NPC TMA (scale bar = 50 μm). c NOTCH2 staining intensity in the TMA samples from 117 patients with NPC. Data are the mean ± SD of at least three independent experiments; P-values were calculated using Student’s t-test. *P < 0.05. d Relative NOTCH2 and N2ICD protein expression in the NPC cell lines. Data are the mean ± SD of at least three independent experiments; statistical analysis was carried out using one-way analysis of variance. *P < 0.05. e TMA analyses of 117 patients with NPC diagnosed at the M0 stage. Kaplan–Meier OS curves for patients with NPC stratified by NOTCH2 expression