Fig. 6

Significance of Arf6-mediated CD147 signaling components expressed in liver cancer. The mRNA expression level of CD147, ARF6, ARNO, ACAP3, and Rac1 in clinical samples was determined by GEPIA. a, d, g, j, m Box plots depict the expression difference between liver cancer (T) and normal tissues (N). Matched TCGA normal & GTEx data are included. Each dot represents the expression level of a sample. b, e, h, k, n Stage plots depict the expression variation among different pathological stages of liver cancer tissues. c, f, i, l, o Survival plots depict the overall survival (OS) for low- and high-expression groups of the signal genes among liver cancer patients (cutoff: median). log-rank test, *p < 0.05, ** P < 0.01