From: Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes
Feature | CD147-high % (n) | Arf6-high % (n) | ARNO-high % (n) | Rac1-high % (n) |
---|---|---|---|---|
All patients (n = 60) | 57 (34) | 52 (31) | 67 (40) | 82 (49) |
Gender | ||||
 Male (n = 45) | 56 (25) | 53 (24) | 67 (30) | 82 (37) |
 Female (n = 15) | 60 (9) | 47 (7) | 67 (10) | 80 (12) |
 P | 0.76 | 0.66 | 1.00 | 0.85 |
Age at surgery (years) | ||||
 <59 (n = 34) | 65 (22) | 50 (17) | 62 (21) | 85 (29) |
 >59 (n = 26) | 46 (12) | 54 (14) | 73 (19) | 77 (20) |
 P | 0.15 | 0.77 | 0.36 | 0.41 |
TNM stage | ||||
 1, 2 (n = 22) | 36 (8) | 36 (8) | 45(10) | 55 (12) |
 3, 4 (n = 38) | 68 (26) | 61 (23) | 79 (30) | 97 (37) |
 P | 0.02 | 0.07 | 0.01 | < 0.01 |
Portal vein tumor thrombus | ||||
 +(n = 6) | 100 (6) | 100 (6) | 100 (6) | 100 (6) |
 - (n = 54) | 52 (28) | 46 (25) | 63 (34) | 80 (43) |
 P | 0.02 | 0.01 | 0.07 | 0.22 |
Histological grade | ||||
 G1,2 (n = 53) | 55 (29) | 49 (26) | 64 (34) | 85 (45) |
 G3,4 (n = 7) | 71 (5) | 71 (5) | 86 (6) | 57 (4) |
 P | 0.40 | 0.27 | 0.26 | 0.07 |
AFP (ng/mL) | ||||
 <400 (n = 46) | 57 (26) | 39 (18) | 59 (27) | 87 (40) |
 ≥400 (n = 14) | 57 (8) | 93 (13) | 93 (13) | 64 (9) |
 P | 0.97 | < 0.01 | 0.02 | 0.05 |
Maximal tumor size (cm) | ||||
 <5 (n = 42) | 55 (23) | 45 (19) | 69 (29) | 83 (35) |
 ≥5 (n = 18) | 61 (11) | 67 (12) | 61 (11) | 78 (14) |
 P | 0.65 | 0.13 | 0.55 | 0.61 |
Background liver status | ||||
 With cirrhosis (n = 40) | 60 (24) | 58 (23) | 70 (28) | 75 (30) |
 Without cirrhosis (n = 20) | 50 (10) | 40 (8) | 60 (12) | 95 (19) |
 P | 0.46 | 0.20 | 0.44 | 0.06 |
Capsule formation | ||||
 +(n = 35) | 57 (20) | 43 (15) | 57 (20) | 77 (27) |
 - (n = 25) | 56 (14) | 64 (16) | 80 (20) | 88 (22) |
 P | 0.93 | 0.11 | 0.06 | 0.28 |