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Table 1 Clinicopathological features of HCC patients and association with Arf6-CD147 signaling components

From: Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes

Feature

CD147-high

% (n)

Arf6-high

% (n)

ARNO-high

% (n)

Rac1-high

% (n)

All patients (n = 60)

57 (34)

52 (31)

67 (40)

82 (49)

Gender

 Male (n = 45)

56 (25)

53 (24)

67 (30)

82 (37)

 Female (n = 15)

60 (9)

47 (7)

67 (10)

80 (12)

 P

0.76

0.66

1.00

0.85

Age at surgery (years)

 <59 (n = 34)

65 (22)

50 (17)

62 (21)

85 (29)

 >59 (n = 26)

46 (12)

54 (14)

73 (19)

77 (20)

 P

0.15

0.77

0.36

0.41

TNM stage

 1, 2 (n = 22)

36 (8)

36 (8)

45(10)

55 (12)

 3, 4 (n = 38)

68 (26)

61 (23)

79 (30)

97 (37)

 P

0.02

0.07

0.01

< 0.01

Portal vein tumor thrombus

 +(n = 6)

100 (6)

100 (6)

100 (6)

100 (6)

 - (n = 54)

52 (28)

46 (25)

63 (34)

80 (43)

 P

0.02

0.01

0.07

0.22

Histological grade

 G1,2 (n = 53)

55 (29)

49 (26)

64 (34)

85 (45)

 G3,4 (n = 7)

71 (5)

71 (5)

86 (6)

57 (4)

 P

0.40

0.27

0.26

0.07

AFP (ng/mL)

 <400 (n = 46)

57 (26)

39 (18)

59 (27)

87 (40)

 ≥400 (n = 14)

57 (8)

93 (13)

93 (13)

64 (9)

 P

0.97

< 0.01

0.02

0.05

Maximal tumor size (cm)

 <5 (n = 42)

55 (23)

45 (19)

69 (29)

83 (35)

 ≥5 (n = 18)

61 (11)

67 (12)

61 (11)

78 (14)

 P

0.65

0.13

0.55

0.61

Background liver status

 With cirrhosis (n = 40)

60 (24)

58 (23)

70 (28)

75 (30)

 Without cirrhosis (n = 20)

50 (10)

40 (8)

60 (12)

95 (19)

 P

0.46

0.20

0.44

0.06

Capsule formation

 +(n = 35)

57 (20)

43 (15)

57 (20)

77 (27)

 - (n = 25)

56 (14)

64 (16)

80 (20)

88 (22)

 P

0.93

0.11

0.06

0.28

  1. P values represent the results of the Chi-square test