Fig. 7From: PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancerModel depicting that PES1 interacted with BRD4 and contributed to the BET inhibitor resistance via increasing the expression levels of c-Myc in pancreatic cancer. CDK5 phosphorylated and stabilized PES1. Dinaciclib was proved to down-regulate PES1 and overcome the JQ1 resistance in pancreatic cancer cellsBack to article page