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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade

Fig. 5

Inhibition of HOTAIR/miR-214/ST6GAL1 axis attenuates α 2, 6-sialylated c-Met during CRC procession and activates JAK2/STAT3 pathway. a ST6GAL1 mRNA level was analyzed with antagomiR-214 or shHOTAIR treatment. b ST6GAL1 protein level was measured of transfected CRC cells. c The FITC-SNA intensity was examined by flow cytometry. d Decreased ST6GAL1 attenuated the sialylated c-Met level. e Modulation of HOTAIR and miR-214 affected sialylated c-Met level. f By blocking c-Met and SNA, the JAK2/STAT3 pathway was inhibited. g Decreased ST6GAL1 and AMG-208 inactivated the JAK2/STAT3 pathway. h Alteration of shHOTAIR and antagomiR-214 impacted the activity of JAK2/STAT3 signaling. Data were means ± SD of three independent assays (*P < 0.05)

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