Fig. 8

Schematic figure for present study. In untreated cancer cells (left), NFATc3 is dephosphorylated by activated calcineurin, which leads to its nuclear translocation and inhibition of NFAT-mediated RAG1 gene transcription. When arsenic is present (right), NFATc3 is inhibited at the transcriptional level, while increased intracellular ROS levels lead to NFATc3 redistribution and protein degradation. Decreased NFATc3 results in upregulation of RAG1 expression, producing fatal DNA damage