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Table 1 Prognostic factor for DFS and OS of patients with intrahepatic cholangiocarcinoma determined by using univariate

From: MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway

Variable

Disease-free survival

Overall survival

HR

95%CI

P-value

HR

95%CI

P-value

Univariate

 Age(>58 or ≤ 58)

0.95

0.68–1.33

0.571

1.01

0.72–1.41

0.945

 Gender (female/male)

1.23

0.88–1.72

0.201

1.23

0.88–1.72

0.208

 Hepatitis B (−/+)

0.94

0.62–1.43

0.788

0.88

0.58–1.32

0.547

 Alb>40 g/L or ≤ 40 g/L

0.88

0.63–1.23

0.455

0.85

0.61–1.18

0.329

 Hepatitis C (+/−)

1.75

0.54–5.62

0.192

1.75

0.54–5.64

0.199

 MFAP5 protein level(>4/≤4)a

1.76

1.25–2.47

0.0004

1.71

1.22–2.40

0.001

 CA19–9(>37 U/L or ≤ 37 U/L)

1.70

1.22–2.38

0.031

1.91

1.37–2.66

0.043

 CEA(>5μg/L or ≤ 5μg/L)

1.76

1.21–2.55

0.011

1.84

1.27–2.67

0.017

 Vascular invasion (+/−)

2.32

1.36–3.95

0.0001

2.54

1.46–4.41

0.0001

 Number of tumor (multiple/single)

1.79

1.19–2.68

0.0006

1.85

1.23–2.78

0.0003

 Lymph node metastasis (+/−)

1.48

1.03–2.12

0.017

1.40

0.98–1.99

0.047

 Adjacent organ invasion (+/−)

1.21

0.82–1.78

0.284

1.29

0.87–1.91

0.160

Tumor differentiation

 Well vs Moderately

0.44

0.22–0.91

0.095

0.38

0.19–0.74

0.041

 Well vs Poorly

0.30

0.15–0.59

0.009

0.27

0.14–0.51

0.002

 Moderately vs Poorly

0.60

0.41–0.88

0.002

0.61

0.42–0.90

0.005

Multivariate

 aMFAP5 protein level(>4/≤4)

1.88

1.29–2.75

0.0008

1.75

1.20–2.56

0.003

 Vascular invasion (+/−)

1.72

1.12–2.65

0.012

1.77

1.15–2.79

0.008

 Lymph node metastasis (+/−)

1.93

1.29–2.87

0.001

1.55

1.04–2.32

0.028

 Tumor differentiation (Well vs Moderately vs Poorly)

1.55

1.25–1.93

0.0001

1.38

1.12–1.69

0.002

  1. MFAP5 Microfibril associated protein 5, CA19–9 Carbohydrate antigen 19–9, CEA Carcino-embryonic antigen, DFS Disease-free survival, OS, Overall survival, HR Hazard ratio, CI Confidence interval
  2. aImmunohistochemical (IHC) score, split at median
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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