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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis

Fig. 7

RPN2 is positively regulated by circNFIX and negatively regulated by miR-378e. (a and b) GERIA predicted high expression of RPN2 in glioma. (c) RPN2 mRNA level was detected in glioma tissues (n = 64) and normal tissues (n = 15). (d) The expression level of RPN2 mRNA was detected in glioma cells and normal astrocyte cell line. (e and f) RPN2 protein level was measured in T98 and U251 cells transfected with pcDNA, circNFIX, si-NC or si-circNFIX. (g and h) RPN2 protein level was detected in T98 and U251 cells transfected with miR-NC, miR-378e, anti-miR-NC or anti-miR-378e. (i) RPN2 protein level was determined in T98 and U251 cells transfected with pcDNA, circNFIX, circNFIX and miR-NC or miR-378e. (j) RPN2 protein level was determined in T98 and U251 cells transfected with si-NC, si-circNFIX, si-circNFIX and anti-miR-NC or anti-miR-378e. *P < 0.05, **P < 0.01, ***P < 0.001 compared with indicated control group

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