Fig. 1

Expression of MOB1 in and its association with clinicopathologic features of PDAC. TMA PDAC specimens were immunostained with a specific anti-MOB1 antibody. a, representative images of MOB1 expression in adjacent normal pancreatic tissue specimens. b, representative image of low MOB1 expression in PDAC specimens. c, representative image of high MOB1 expression in PDAC specimens. d and e, the expression of MOB1 was significantly lower in tumors (TT) than in adjacent normal tissue (TN). f and g, representative images of high MOB1 expression in PDAC specimens without lymph nodes metastasis and low MOB1 expression with lymph nodes metastasis. h, the expression of MOB1 was negatively associated with lymph nodes metastasis. i and j, representative images of high MOB1 expression in PDAC specimens of well differentiation and low MOB1 expression of poor differentiation. k, the expression of MOB1 was negative associated with PDAC poorer differentiation. l, the protein levels of MOB1 in PDAC cell lines and normal pancreas cells (HPNE). m, the mRNA levels of MOB1A and MOB1B in PDAC cell lines and normal pancreas cells. n, o and p, the tumor differentiation, N stages and MOB1 expression were associated with the OS of PDAC patients