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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression

Fig. 6

The expressions of KDM2B negative related to MOB1 in PDAC tissues. The same cohorts of TMA sections for MOB1 were immunostained with a specific anti-KDM2B antibody. a, representative images of KDM2B low expression in adjacent normal pancreatic tissue specimens. b, representative images of KDM2B low expression in PDAC specimens. c, representative images of KDM2B high expression in PDAC specimens. d and e, the expression of KDM2B was significantly higher in tumors (TT) than in adjacent normal tissue (TN). f and g, representative images of low KDM2B expression in PDAC specimens of well differentiation and high KDM2B expression of poor differentiation. h, the expression of KDM2B was positively associated with PDAC poorer differentiation. i and j, representative images of low KDM2B expression in PDAC specimens without lymph nodes metastasis and high KDM2B expression with lymph nodes metastasis. k, the expression of KDM2B positively associated with lymph nodes metastasis. l, KDM2B expression was negatively associated with the OS of PDAC patients. m and n, KDM2B and MOB1 protein expression TMA tissue sections were represented from the cohort. The negative correlation of KDM2B with MOB1 expression was assessed using Pearson correlation coefficient analysis (n = 100; r = − 0.544, P < 0.001)

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