Fig. 6
From: MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2
Schematic model of MYCN/PRC1-mediated ELOVL2 repression in neuroblastoma. MYCN and PRC1 are recruited in the same complexes to the ELOVL2 promoter region and repress ELOVL2 expression. The repressive epigenetic marker H2AK119ub is more enriched in MYCN-amplified neuroblastoma cells, and the ELOVL2 expression is decreased. The DHA concentration is correspondingly decreased, which finally lead to cell cycle acceleration