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Table 2 The association between BRD7, YB1 expression and clinicopathologic features of breast cancer

From: BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition

VariablesYB1 expressionBRD7/YB1 expression
FeaturesYB1HYB1LPBRD7LYB1HBRD7HYB1LP
Age (Y)
 <4650 (45.5)56 (50.9)0.41835 (49.3)32(45.1)0.737
 ≥4660 (54.5)54 (49.1)36 (50.7)39(54.9)
Tumor size (%)
 T1~250 (45.5)71 (64.5)0.008**31 (43.7)46 (64.8)0.020*
 T3~460 (54.5)39 (35.5)40 (56.3)25 (35.2)
Nodal metastasis (%)
 Absent23 (20.9)25 (22.7)0.56715 (21.1)19 (26.8)0.432
 Present87 (79.1)85 (77.3)56 (78.9)52 (73.2)
Distant metastasis (%)
 Absent94 (85.5)106 (96.4)0.005**60 (84.5)69 (97.2)0.009**
 Present16 (14.5)4 (3.6)11 (15.5)2 (2.8)
TNM stage (%)
 I~II65 (59.1)84 (76.4)0.018*41 (57.7)55 (77.5)0.038*
 III~ IV45 (40.9)26 (23.6)30 (42.3)16 (22.5)
 ER expression (%)
 Negative57 (51.8)35 (32.4)0.004**46 (64.8)21 (30.4)0.000***
 Positive53 (48.2)73 (67.6)25 (35.2)48 (69.6) 
PR expression (%)
 Negative58 (52.7)37 (34.3)0.006**45 (63.4)23 (33.3)0.000***
 Positive52 (47.3)71 (65.7)26 (36.6)46 (66.7) 
 HER2 expression (%)
 Negative39 (35.5)40 (37.0)0.80825 (35.2)29 (42.0)0.407
 Positive71 (64.5)68 (63.0)46 (64.8)40 (58.0) 
  1. In 220 patients, ER, PR and HER2 expression was not detected in two of the patients with low YB1 expression, and the median of YB1 or BRD7 expression was used as the cutoff value
  2. Y Year, TNM Tumor-node-metastases, H High expression, L Low expression, P P values of two-sided χ2 test, % The ratio of the number of samples to the total number of samples per column, * p < 0.05, ** p < 0.01, *** p < 0.001