Skip to main content

Table 2 The association between BRD7, YB1 expression and clinicopathologic features of breast cancer

From: BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition

Variables

YB1 expression

BRD7/YB1 expression

Features

YB1H

YB1L

P

BRD7LYB1H

BRD7HYB1L

P

Age (Y)

 <46

50 (45.5)

56 (50.9)

0.418

35 (49.3)

32(45.1)

0.737

 ≥46

60 (54.5)

54 (49.1)

36 (50.7)

39(54.9)

Tumor size (%)

 T1~2

50 (45.5)

71 (64.5)

0.008**

31 (43.7)

46 (64.8)

0.020*

 T3~4

60 (54.5)

39 (35.5)

40 (56.3)

25 (35.2)

Nodal metastasis (%)

 Absent

23 (20.9)

25 (22.7)

0.567

15 (21.1)

19 (26.8)

0.432

 Present

87 (79.1)

85 (77.3)

56 (78.9)

52 (73.2)

Distant metastasis (%)

 Absent

94 (85.5)

106 (96.4)

0.005**

60 (84.5)

69 (97.2)

0.009**

 Present

16 (14.5)

4 (3.6)

11 (15.5)

2 (2.8)

TNM stage (%)

 I~II

65 (59.1)

84 (76.4)

0.018*

41 (57.7)

55 (77.5)

0.038*

 III~ IV

45 (40.9)

26 (23.6)

30 (42.3)

16 (22.5)

 ER expression (%)

 Negative

57 (51.8)

35 (32.4)

0.004**

46 (64.8)

21 (30.4)

0.000***

 Positive

53 (48.2)

73 (67.6)

25 (35.2)

48 (69.6)

 

PR expression (%)

 Negative

58 (52.7)

37 (34.3)

0.006**

45 (63.4)

23 (33.3)

0.000***

 Positive

52 (47.3)

71 (65.7)

26 (36.6)

46 (66.7)

 

 HER2 expression (%)

 Negative

39 (35.5)

40 (37.0)

0.808

25 (35.2)

29 (42.0)

0.407

 Positive

71 (64.5)

68 (63.0)

46 (64.8)

40 (58.0)

 
  1. In 220 patients, ER, PR and HER2 expression was not detected in two of the patients with low YB1 expression, and the median of YB1 or BRD7 expression was used as the cutoff value
  2. Y Year, TNM Tumor-node-metastases, H High expression, L Low expression, P P values of two-sided χ2 test, % The ratio of the number of samples to the total number of samples per column, * p < 0.05, ** p < 0.01, *** p < 0.001