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Table 2 The association between BRD7, YB1 expression and clinicopathologic features of breast cancer

From: BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition

Variables YB1 expression BRD7/YB1 expression
Features YB1H YB1L P BRD7LYB1H BRD7HYB1L P
Age (Y)
 <46 50 (45.5) 56 (50.9) 0.418 35 (49.3) 32(45.1) 0.737
 ≥46 60 (54.5) 54 (49.1) 36 (50.7) 39(54.9)
Tumor size (%)
 T1~2 50 (45.5) 71 (64.5) 0.008** 31 (43.7) 46 (64.8) 0.020*
 T3~4 60 (54.5) 39 (35.5) 40 (56.3) 25 (35.2)
Nodal metastasis (%)
 Absent 23 (20.9) 25 (22.7) 0.567 15 (21.1) 19 (26.8) 0.432
 Present 87 (79.1) 85 (77.3) 56 (78.9) 52 (73.2)
Distant metastasis (%)
 Absent 94 (85.5) 106 (96.4) 0.005** 60 (84.5) 69 (97.2) 0.009**
 Present 16 (14.5) 4 (3.6) 11 (15.5) 2 (2.8)
TNM stage (%)
 I~II 65 (59.1) 84 (76.4) 0.018* 41 (57.7) 55 (77.5) 0.038*
 III~ IV 45 (40.9) 26 (23.6) 30 (42.3) 16 (22.5)
 ER expression (%)
 Negative 57 (51.8) 35 (32.4) 0.004** 46 (64.8) 21 (30.4) 0.000***
 Positive 53 (48.2) 73 (67.6) 25 (35.2) 48 (69.6)  
PR expression (%)
 Negative 58 (52.7) 37 (34.3) 0.006** 45 (63.4) 23 (33.3) 0.000***
 Positive 52 (47.3) 71 (65.7) 26 (36.6) 46 (66.7)  
 HER2 expression (%)
 Negative 39 (35.5) 40 (37.0) 0.808 25 (35.2) 29 (42.0) 0.407
 Positive 71 (64.5) 68 (63.0) 46 (64.8) 40 (58.0)  
  1. In 220 patients, ER, PR and HER2 expression was not detected in two of the patients with low YB1 expression, and the median of YB1 or BRD7 expression was used as the cutoff value
  2. Y Year, TNM Tumor-node-metastases, H High expression, L Low expression, P P values of two-sided χ2 test, % The ratio of the number of samples to the total number of samples per column, * p < 0.05, ** p < 0.01, *** p < 0.001