Fig. 7

Restoration of miR-338-3p restrained growth, EMT, Wnt and MEK signaling in vitro. a-d Expressions of MACC1, Met, proliferation related marker PCNA, and EMT related markers E-cadherin and Cytokeratin7, N-cadherin, Vimentin, Catenin beta, MMP2 and MMP9 in control, miR-338-3p overexpression, MACC1 overexpression, Met overexpression, miR-338-3p overexpression + MACC1 overexpression and miR-338-3p overexpression + Met overexpression lentivectors transfected OVCAR3 and OVCAR8 cells respectively. e-h Activities of Wnt/Cadherin beta and MEK/ERK pathways examined by western blot in different groups, Wnt signaling inhibitor (30 μM IWP-2) and MEK signaling inhibitor (1 μM UO126) were used to treat control, MACC1 overexpression and Met overexpression cells for 24 h as a positive control