Fig. 1

CMS4 gene expression signature in a preclinical model of colon cancer cells with acquired resistance to MEKi. Agilent microarray analyses were performed to assess baseline gene expression profile for SW48 and SW48-MR Colon cancer cell lines, as described in Materials and Methods. (Log) fold change indicates relative microRNA expression levels in SW48-MR respect to SW48 cells. The genes whose expression is up regulated in SW48-MR compared to SW48 cells are represented in schematic tables. These genes are involved in CMS4 gene signature