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Table 1 Patient’s demographics and tumor characteristics and association of miR-381 levels with clinicopathological features in lung tumor population

From: Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis

Characteristics

No. of patients, N = 60 (%)

P value

Patients Parameter

 Age (years)

0.542

 Average [range]

53 [25–81]

 

  < 55

21 (35.0)

 

  ≥ 55

39 (65.0)

 

Gender

0.881

 Male

33 (55.0)

 

 Female

27 (45.0)

 

Tumor Characteristics

 Tumor size (cm)

0.004**

  < 4

9 (15.0)

 

  ≥ 4

51 (85.0)

 

Differentiation

0.062

 Poor

39 (65.0)

 

 Well-moderate

21 (35.0)

 

Lymph node metastasis

0.034*

 N-

10 (16.7)

 

 N+

50 (83.3)

 

Distant metastasis

0.039*

 M-

15 (25.0)

 

 M+

45 (75.0)

 

miR-381 level

 high

5 (8.3)

0.821

 median

6 (10.0)

0.093

 low

49 (81.7)

0.002**

  1. Differences between experimental groups were assessed by Student’s t-test or one-way analysis of variance. Data represent mean ± SD. *p < 0.05; **p < 0.01