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Table 2 Tumorigenicity and metastatic ability of U-2OS cells after the depletion of ROCK2

From: ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Cells

Tumor

Lung metastases

Incidence

Latency (mean days ± SEM)

Volume at 9 weeks (mean

cm3 ± SEM)

Incidence

Median number

Individual values

U-2/SCR pool

6/6

23.2 ± 1.2

1.635 ± 0.051

6/6

> 200

> 200, > 200, > 200, > 200, > 200, > 200

U-2/sh ROCK2 #78

6/6

37 ± 2.9

0.958 ± 0.233*

0/6†

0‡

0, 0, 0, 0, 0, 0

U-2/sh ROCK2 #46

0/6

NA

0**

0/6†

0‡

0, 0, 0, 0, 0, 0

  1. †p = 0.01, Fisher’s exact test, vs U-2/SCR pool
  2. *p < 0.05, **p <0.0001, Student’s t test, vs. U-2/SCR pool
  3. ‡p < 0.01, Wilcoxon’s rank sum test, vs. U-2/SCR pool