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Table 2 Tumorigenicity and metastatic ability of U-2OS cells after the depletion of ROCK2

From: ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Cells Tumor Lung metastases
Incidence Latency (mean days ± SEM) Volume at 9 weeks (mean
cm3 ± SEM)
Incidence Median number Individual values
U-2/SCR pool 6/6 23.2 ± 1.2 1.635 ± 0.051 6/6 > 200 > 200, > 200, > 200, > 200, > 200, > 200
U-2/sh ROCK2 #78 6/6 37 ± 2.9 0.958 ± 0.233* 0/6† 0‡ 0, 0, 0, 0, 0, 0
U-2/sh ROCK2 #46 0/6 NA 0** 0/6† 0‡ 0, 0, 0, 0, 0, 0
  1. p = 0.01, Fisher’s exact test, vs U-2/SCR pool
  2. *p < 0.05, **p <0.0001, Student’s t test, vs. U-2/SCR pool
  3. p < 0.01, Wilcoxon’s rank sum test, vs. U-2/SCR pool