Fig. 5

CAFs carrying exosomal miR-93-5p facilitate chemoresistance of CRC cells. SW480 cells were transfected with FOXA1 overexpression plasmid and co-cultured with miR-93-5-exo under exposure to irradiation. a Cell viability in SW480 cells detected using CCK-8 assay. b–c Colony formation ability of SW480 cells detected using colony formation assay. d–e Cell cycle distribution in SW480 cells detected using flow cytometry. f–g Apoptosis of SW480 cells detected using flow cytometry. Values obtained from three independent experiments in triplicate are expressed as mean ± SD and analyzed by one-way ANOVA followed by Tukey’s post hoc test among multiple groups, and by repeated measures ANOVA followed by Bonferroni at different time points. ^*p < 0.05 compared with SW480 cells treated with NC-exo + oe-NC; ^*p < 0.05 compared with SW480 cells treated with NC-exo + oe-FOXA1; ^&p < 0.05 compared with non-irradiated cells