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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway

Fig. 2

LINC00662 dramatically influenced the proliferation, apoptosis, invasion and migration of colon cancer cells (a) Clone formation assay was used to detect cell proliferation in LINC00662 overexpression plasmids transfected HCT29 and LS174T cells; (b) Clone formation assay was used to detect cell proliferation in LINC00662 knockdown plasmids transfected LOVO and CT26 cells; (c) Flow cytometry assay was used to detect cell apoptosis in LINC00662 overexpression plasmids transfected HCT29 and LS174T cells; (d) Flow cytometry assay was used to detect cell apoptosis in LINC00662 knockdown plasmids transfected LOVO and CT26 cells; (e) Transwell assay was used to detect cell invasion in LINC00662 overexpression plasmids transfected HCT29 and LS174T cells; (f) Transwell assay was used to detect cell invasion in LINC00662 knockdown plasmids transfected LOVO and CT26 cells; (g) Wound healing assay was used to detect cell migration in LINC00662 overexpression plasmids transfected HCT29 and LS174T cells; (h) Wound healing assay was used to detect cell migration in LINC00662 knockdown plasmids transfected LOVO and CT26 cells. Data are presented as the mean ± standard deviation. *P < 0.01 vs. pcDNA3.1-vector group/or NC-siRNA group

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