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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway

Fig. 4

LINC00662 dramatically affected tumor growth of colon cancer in vivo (a) LINC00662 overexpression plasmids transfected HCT29 were injected with nude mouse; (b) Statistical graph of tumor weight in nude mouse carrying with LINC00662 overexpression plasmids transfected HCT29; (c) Statistical graph of tumor volume in nude mouse carrying with LINC00662 overexpression plasmids transfected HCT29; (d) LINC00662 knockdown plasmids transfected CT26 were injected with nude mouse; (e) Statistical graph of tumor weight in nude mouse carrying with LINC00662 knockdown plasmids transfected CT26; (f) Statistical graph of tumor volume in nude mouse carrying with LINC00662 knockdown plasmids transfected CT26; (g) TUNEL assay was used to detect cell apoptosis of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26; (h) Immunohistochemistry assay was used to detect VEGF expression of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26; (i) Immunohistochemistry assay was used to detect MMP-2 expression of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26. Data are presented as the mean ± standard deviation. *P < 0.01 vs. pcDNA3.1-vector group/NC-siRNA group

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