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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Fig. 3

AMSC-Exo-199a sensitizes PLC/PRF/5 cells to doxorubicin. a The cell vialibility of PLC/PRF/5 cells by doxorubicin (Dox) expusure were determined by real time cellular analysis. The relative cell proliferation ratio was normalized over the cell index of the PLC/PRF/5 cells with Dox-treatment alone at 24 h. b FITC-Annexin V/PI stain for cell apoptosis assay on AMSC-Exo-treated PLC/PRF/5 cells combined with or without Dox expusure. AMSC-Exo-199a could significantly increase the percent of apoptotic cells (Annexin V+/PI-) by Dox expusure. Data are presented as mean ± S.D. (*P < 0.05, **P < 0.01, ns = nonsense, n = 3). Exo-199a AMSC-Exo-199a, Exo-67 AMSC-Exo-67

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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