Skip to main content
Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Fig. 5

AMSC-Exo-199a sensitizes HCC to Dox in vivo by suppressing mTOR pathway. a Tumor growth in Dox-treated mice was measured by whole-mount imaging of luciferin florescence and photon counts were analyzed at initial and 14 d and 28 d after AMSC-Exo-199 or AMSC-Exo-67 i.v. injection. b Hematoxylin-eosin staining (HE) and fluorescent detection of liver samples collected at 6 h after AMSC-Exo i.v. injection. c Real-time PCR detection of miR-199a-3p expression in the liver samples of mice with AMSC-Exo i.v. injection. d Western blot analysis of mTOR, p-4EBP1 and p-70S6K expression levels in HCC samples of the mice with AMSC-Exo and Dox combined therapy. e Tumor growth in AMSC-Exo monotherapy mice was measured as above at initial and 14 d and 28 d after AMSC-Exo-199 or AMSC-Exo-67 i.v. injection. Data are presented as mean ± S.D. (**P < 0.01, ns = nonsense, n = 6, 3 from 6 samples were shown in d). Exo-199a AMSC-Exo-199a, Exo-67 AMSC-Exo-67

Back to article page